Early Menopause Increases Risk of Premature Death, Study Finds

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This new study shows that women who go through menopause before they turn 40 are more likely to die young.

Scientists say that hormone treatment can lower the risk. The long-term Finnish study is the biggest one that has been done on the link between menopause before its time and death.

Researchers say that their results show how important it is for these women to get regular checkups and use hormone treatment correctly.
Most women go through menopause between 45 and 55 years old.


That being said, about 100 women go through menopause before they turn 40. This is called premature menopause or premature ovarian insufficiency (POI).

Researchers have found that women who go through menopause early are more likely to have long-term health issues like heart disease.

Scientists say they don't know what causes it, but it can happen on its own or because of medical treatments like chemotherapy or surgery to remove the ovaries.

Hormone replacement therapy (HRT) is the most common procedure, but most women who go through early menopause don't follow the directions and don't take the drugs as prescribed.

The new study looked at more than 5,800 women in Finland who were diagnosed with natural or medical premature ovarian failure between 1988 and 2017. The researchers were from the University of Oulu and Oulu University Hospital.

They looked at those women along with nearly 23,000 others who did not go through POI.

They discovered that women who had spontaneous premature ovarian failure were more than twice as likely to die of any cause or heart disease, and more than four times as likely to die of cancer.

But for women who used HRT for more than six months, the risk of death from any cause and cancer was cut in half.

No extra risk of dying young was there for women who went through early menopause because of surgery.

Studies have also shown that women who go through menopause too soon are more likely to die young. However, this link had never been studied in such a big group of women and watched for up to 30 years.

"As far as we know, this is the largest study that looks at the link between premature ovarian insufficiency and mortality risk," said Hilla Haapakoski, who led the study.As one of the first studies to look at the effects of both surgery and natural early ovarian failure on women's death rates from all causes, heart disease, and cancer, and to see if HRT for more than six months may lower death risk.To lower the number of unnecessary deaths, our results show that women who have spontaneous premature ovarian failure should have extra care given to their health.

The next thing the researchers are going to do is look into whether women who go through early menopause are more likely to have other illnesses or conditions, like cancer or heart disease, and whether long-term use of HRT changes those conditions.

The University of Oulu's PhD student Haapakoski said, "Many of the health risks that women with premature ovarian insufficiency face have not been fully recognized, and the use of HRT is often overlooked."

She told us: "We hope to improve the health of these women by increasing awareness of the risks among healthcare professionals and the women themselves."


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